Association between CD14 gene polymorphisms and cancer risk: a meta-analysis.

Association between CD14 gene polymorphisms and cancer risk: a meta-analysis.

Blog Article

BACKGROUND: Two polymorphisms, -260C/T and -651C/T, in the CD14 gene have been implicated in susceptibility to cancer.However, the results remain inconclusive.This meta-analysis aimed to investigate the association between the two polymorphisms and risk of cancer.METHODS: All eligible case-control MATTE CLAY studies published up to March 2014 were identified by searching PubMed, Web of Science, CNKI and WanFang database.

Pooled odds ratio (OR) with 95% confidence interval (CI) were used to access the strength of this association in fixed- or random-effects model.RESULTS: 17 case-control studies from fourteen articles were included.Of those, there were 17 studies (4198 cases and 4194 controls) for -260C/T polymorphism and three studies (832 cases and 1190 controls) for -651C/T polymorphism.Overall, no significant associations between the two polymorphisms of CD14 gene and cancer risk were found.

When stratified by ethnicity, cancer type and source of control, similar results were Hoodies/Fleece observed among them.In addition, in further subgroups analysis by Helicobacter pylori (H.pylori) infection status and tumor location in gastric cancer subgroup, we found that the CD14 -260C/T polymorphism may increase the risk of gastric cancer in H.pylori-infected individuals.

CONCLUSIONS: This meta-analysis suggests that the CD14 -260C/T polymorphism may increase the risk of gastric cancer in H.pylori-infected individuals.However, large and well-designed studies are warranted to validate our findings.